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	kaposi sarcoma

Disease ID	108
Disease	kaposi sarcoma
Definition	A multicentric, malignant neoplastic vascular proliferation characterized by the development of bluish-red cutaneous nodules, usually on the lower extremities, most often on the toes or feet, and slowly increasing in size and number and spreading to more proximal areas. The tumors have endothelium-lined channels and vascular spaces admixed with variably sized aggregates of spindle-shaped cells, and often remain confined to the skin and subcutaneous tissue, but widespread visceral involvement may occur. Kaposi's sarcoma occurs spontaneously in Jewish and Italian males in Europe and the United States. An aggressive variant in young children is endemic in some areas of Africa. A third form occurs in about 0.04% of kidney transplant patients. There is also a high incidence in AIDS patients. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, pp2105-7) HHV-8 is the suspected cause.
Synonym	[m]kaposi's sarcoma [x]kaposi's sarcoma, unspecified [x]kaposi's sarcoma, unspecified (disorder) endotheliosarcoma hhv 8 hhv8 kaposi cancer, sarcoma kaposi sarcoma, morphology kaposi's sarcoma kaposi's sarcoma (clinical) kaposi's sarcoma (disorder) kaposi's sarcoma (morphologic abnormality) kaposi's sarcoma nos kaposi's sarcoma, morphology kaposi's sarcoma, morphology (morphologic abnormality) kaposi's sarcoma, unspecified kaposi's sarcoma, unspecified site kaposis sarcoma ks - kaposi's sarcoma multiple haemorrhagic sarcoma multiple hemorrhagic sarcoma multiple idiopathic pigmented hemangiosarcoma sarcoma, kaposi sarcoma, kaposi [disease/finding] sarcoma, kaposi's sarcoma, multiple hemorrhagic sarcoma, multiple idiopathic hemorrhagic skin cancer, kaposi's sarcoma
Orphanet	ORPHANET:33276
DOID	DOID:8632
ICD10	ICD10CM:C46.9
UMLS	C0036220
MeSH	D012514
SNOMED-CT	SNOMEDCT_US_2016_09_01:109385007
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:65) C1261473 \| sarcoma \| 7 C0024299 \| lymphoma \| 7 C0001175 \| acquired immunodeficiency syndrome \| 4 C0036220 \| kaposi's sarcoma \| 4 C0024305 \| non-hodgkin lymphoma \| 3 C0030807 \| pemphigus \| 3 C0024299 \| lymphomas \| 3 C0019829 \| hodgkin lymphoma \| 3 C0011603 \| dermatitis \| 2 C0017665 \| membranous glomerulonephritis \| 2 C0030809 \| pemphigus vulgaris \| 2 C0024205 \| lymphadenitis \| 2 C0024314 \| lymphoproliferative disorders \| 2 C0024314 \| lymphoproliferative disorder \| 2 C0036220 \| kaposi sarcoma \| 2 C0079731 \| b-cell lymphoma \| 1 C0152025 \| polyneuropathy \| 1 C0040261 \| onychomycosis \| 1 C0021831 \| enteropathy \| 1 C0026896 \| myasthenia gravis \| 1 C0017636 \| glioblastoma \| 1 C0026764 \| multiple myeloma \| 1 C0009319 \| colitis \| 1 C0039128 \| syphilis \| 1 C0079731 \| non-hodgkin's b-cell lymphoma \| 1 C0024236 \| lymphedema \| 1 C0007102 \| colon cancer \| 1 C0009324 \| ulcerative colitis \| 1 C0030326 \| panniculitis \| 1 C0026393 \| molluscum contagiosum \| 1 C0042900 \| vitiligo \| 1 C0014742 \| erythema multiforme \| 1 C0007137 \| squamous cell carcinomas \| 1 C0149985 \| secondary syphilis \| 1 C0042373 \| vascular disease \| 1 C0042373 \| vascular diseases \| 1 C0005684 \| bladder cancer \| 1 C0026764 \| myeloma \| 1 C0007137 \| squamous cell carcinoma \| 1 C0017658 \| glomerulonephritis \| 1 C0023418 \| leukemia \| 1 C0001173 \| gastric outlet obstruction \| 1 C0003873 \| rheumatoid arthritis \| 1 C0022661 \| chronic renal failure \| 1 C0023827 \| liposarcoma \| 1 C0004134 \| ataxia \| 1 C0033860 \| psoriasis \| 1 C0011615 \| atopic dermatitis \| 1 C0036202 \| sarcoidosis \| 1 C0037274 \| dermatological disorder \| 1 C0021400 \| influenza \| 1 C0011847 \| diabetes \| 1 C0024291 \| hemophagocytic syndrome \| 1 C0238301 \| nasopharyngeal carcinoma \| 1 C0040558 \| toxoplasmosis \| 1 C0026769 \| multiple sclerosis \| 1 C1261473 \| sarcomas \| 1 C0003615 \| appendicitis \| 1 C0033680 \| protein-losing enteropathy \| 1 C0035078 \| renal failure \| 1 C0221406 \| cushing disease \| 1 C0085669 \| acute leukemia \| 1 C0751967 \| relapsing-remitting multiple sclerosis \| 1 C0003864 \| arthritis \| 1 C0030805 \| bullous pemphigoid \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) 3569 \| IL6 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:8) 3569 \| IL6 \| CIPHER;CTD_human 2214 \| FCGR3A \| CIPHER 3106 \| HLA-B \| CIPHER 3119 \| HLA-DQB1 \| CIPHER 3123 \| HLA-DRB1 \| CIPHER 3126 \| HLA-DRB4 \| CIPHER 3127 \| HLA-DRB5 \| CIPHER 7157 \| TP53 \| CIPHER
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:244) 55 \| ACPP \| 1.144 \| DISEASES 94 \| ACVRL1 \| 1.269 \| DISEASES 123624 \| AGBL1 \| 2.074 \| DISEASES 283 \| ANG \| 1.99 \| DISEASES 51378 \| ANGPT4 \| 1.099 \| DISEASES 307 \| ANXA4 \| 1.89 \| DISEASES 9138 \| ARHGEF1 \| 1.167 \| DISEASES 8874 \| ARHGEF7 \| 1.563 \| DISEASES 10620 \| ARID3B \| 1.322 \| DISEASES 220202 \| ATOH7 \| 1.69 \| DISEASES 567 \| B2M \| 2.218 \| DISEASES 9564 \| BCAR1 \| 1.899 \| DISEASES 6046 \| BRD2 \| 3.36 \| DISEASES 682 \| BSG \| 2.006 \| DISEASES 390259 \| BSX \| 1.25 \| DISEASES 9689 \| BZW1 \| 2.104 \| DISEASES 721 \| C4B \| 2.405 \| DISEASES 834 \| CASP1 \| 2.107 \| DISEASES 840 \| CASP7 \| 2.207 \| DISEASES 841 \| CASP8 \| 2.358 \| DISEASES 6364 \| CCL20 \| 1.461 \| DISEASES 388372 \| CCL4L1 \| 1.704 \| DISEASES 8812 \| CCNK \| 1.393 \| DISEASES 1232 \| CCR3 \| 2.127 \| DISEASES 1237 \| CCR8 \| 3.581 \| DISEASES 930 \| CD19 \| 2.959 \| DISEASES 4345 \| CD200 \| 1.863 \| DISEASES 958 \| CD40 \| 1.597 \| DISEASES 959 \| CD40LG \| 2.34 \| DISEASES 942 \| CD86 \| 2.409 \| DISEASES 157313 \| CDCA2 \| 1.5 \| DISEASES 1003 \| CDH5 \| 2.324 \| DISEASES 1029 \| CDKN2A \| 1.132 \| DISEASES 1050 \| CEBPA \| 2.068 \| DISEASES 1063 \| CENPF \| 1.952 \| DISEASES 26097 \| CHTOP \| 1.986 \| DISEASES 1147 \| CHUK \| 1.891 \| DISEASES 10519 \| CIB1 \| 2.001 \| DISEASES 1154 \| CISH \| 1.33 \| DISEASES 387836 \| CLEC2A \| 1.01 \| DISEASES 10087 \| COL4A3BP \| 1.189 \| DISEASES 23412 \| COMMD3 \| 1.285 \| DISEASES 1380 \| CR2 \| 1.848 \| DISEASES 8738 \| CRADD \| 1.25 \| DISEASES 1385 \| CREB1 \| 2.049 \| DISEASES 1499 \| CTNNB1 \| 1.478 \| DISEASES 8065 \| CUL5 \| 2.441 \| DISEASES 2919 \| CXCL1 \| 2.241 \| DISEASES 6387 \| CXCL12 \| 1.012 \| DISEASES 2833 \| CXCR3 \| 1.215 \| DISEASES 7919 \| DDX39B \| 3.029 \| DISEASES 414325 \| DEFB103A \| 1.039 \| DISEASES 55894 \| DEFB103B \| 1.038 \| DISEASES 7913 \| DEK \| 1.871 \| DISEASES 1719 \| DHFR \| 1.845 \| DISEASES 1730 \| DIAPH2 \| 2.828 \| DISEASES 81624 \| DIAPH3 \| 1.794 \| DISEASES 29102 \| DROSHA \| 1.451 \| DISEASES 1850 \| DUSP8 \| 1.7 \| DISEASES 1906 \| EDN1 \| 1.028 \| DISEASES 1907 \| EDN2 \| 1.491 \| DISEASES 1908 \| EDN3 \| 1.74 \| DISEASES 1945 \| EFNA4 \| 1.248 \| DISEASES 1974 \| EIF4A2 \| 1.555 \| DISEASES 1977 \| EIF4E \| 1.286 \| DISEASES 1981 \| EIF4G1 \| 1.641 \| DISEASES 1969 \| EPHA2 \| 2.589 \| DISEASES 2050 \| EPHB4 \| 1.011 \| DISEASES 29924 \| EPN1 \| 1.48 \| DISEASES 2060 \| EPS15 \| 1.678 \| DISEASES 3266 \| ERAS \| 2.695 \| DISEASES 30816 \| ERVW-1 \| 1.182 \| DISEASES 2113 \| ETS1 \| 2.026 \| DISEASES 2157 \| F8 \| 2.03 \| DISEASES 54954 \| FAM120C \| 3.081 \| DISEASES 355 \| FAS \| 1.01 \| DISEASES 2214 \| FCGR3A \| 1.449 \| DISEASES 2246 \| FGF1 \| 2.295 \| DISEASES 2248 \| FGF3 \| 1.12 \| DISEASES 2263 \| FGFR2 \| 1.162 \| DISEASES 2358 \| FPR2 \| 1.022 \| DISEASES 2633 \| GBP1 \| 2.132 \| DISEASES 7918 \| GPANK1 \| 1.48 \| DISEASES 2932 \| GSK3B \| 1.255 \| DISEASES 3005 \| H1F0 \| 2.485 \| DISEASES 3039 \| HBA1 \| 4.326 \| DISEASES 414768 \| HCG24 \| 2.307 \| DISEASES 23462 \| HEY1 \| 1.953 \| DISEASES 9146 \| HGS \| 1.362 \| DISEASES 3091 \| HIF1A \| 1.983 \| DISEASES 8359 \| HIST1H4A \| 1.165 \| DISEASES 8366 \| HIST1H4B \| 1.165 \| DISEASES 8364 \| HIST1H4C \| 1.165 \| DISEASES 8360 \| HIST1H4D \| 1.163 \| DISEASES 8367 \| HIST1H4E \| 1.165 \| DISEASES 8361 \| HIST1H4F \| 1.165 \| DISEASES 8294 \| HIST1H4I \| 1.165 \| DISEASES 8363 \| HIST1H4J \| 1.165 \| DISEASES 8362 \| HIST1H4K \| 1.165 \| DISEASES 8368 \| HIST1H4L \| 1.165 \| DISEASES 8337 \| HIST2H2AA3 \| 3.042 \| DISEASES 8338 \| HIST2H2AC \| 3.042 \| DISEASES 8349 \| HIST2H2BE \| 2.75 \| DISEASES 8370 \| HIST2H4A \| 1.165 \| DISEASES 554313 \| HIST2H4B \| 1.165 \| DISEASES 121504 \| HIST4H4 \| 1.165 \| DISEASES 3096 \| HIVEP1 \| 1.643 \| DISEASES 3105 \| HLA-A \| 2.642 \| DISEASES 3133 \| HLA-E \| 1.009 \| DISEASES 11100 \| HNRNPUL1 \| 2.759 \| DISEASES 3320 \| HSP90AA1 \| 1.769 \| DISEASES 3376 \| IARS \| 1.042 \| DISEASES 3428 \| IFI16 \| 2.445 \| DISEASES 3451 \| IFNA17 \| 2.333 \| DISEASES 3440 \| IFNA2 \| 3.338 \| DISEASES 3456 \| IFNB1 \| 2.958 \| DISEASES 3459 \| IFNGR1 \| 1.159 \| DISEASES 3551 \| IKBKB \| 1.857 \| DISEASES 8517 \| IKBKG \| 2.487 \| DISEASES 3586 \| IL10 \| 1.924 \| DISEASES 3570 \| IL6R \| 1.825 \| DISEASES 3572 \| IL6ST \| 1.302 \| DISEASES 54556 \| ING3 \| 1.119 \| DISEASES 10527 \| IPO7 \| 1.254 \| DISEASES 3654 \| IRAK1 \| 1.283 \| DISEASES 3660 \| IRF2 \| 2.637 \| DISEASES 3662 \| IRF4 \| 3.035 \| DISEASES 3665 \| IRF7 \| 3.654 \| DISEASES 10379 \| IRF9 \| 1.511 \| DISEASES 9636 \| ISG15 \| 1.46 \| DISEASES 3716 \| JAK1 \| 1.889 \| DISEASES 3725 \| JUN \| 2.376 \| DISEASES 3803 \| KIR2DL2 \| 1.098 \| DISEASES 374454 \| KRT77 \| 2.231 \| DISEASES 51520 \| LARS \| 1.661 \| DISEASES 4049 \| LTA \| 1.515 \| DISEASES 80740 \| LY6G6C \| 1.952 \| DISEASES 4067 \| LYN \| 2.041 \| DISEASES 4094 \| MAF \| 1.339 \| DISEASES 84061 \| MAGT1 \| 1.101 \| DISEASES 4121 \| MAN1A1 \| 1.259 \| DISEASES 5609 \| MAP2K7 \| 1.845 \| DISEASES 5599 \| MAPK8 \| 1.967 \| DISEASES 115004 \| MB21D1 \| 2.562 \| DISEASES 4170 \| MCL1 \| 1.317 \| DISEASES 4193 \| MDM2 \| 2.53 \| DISEASES 4204 \| MECP2 \| 1.404 \| DISEASES 9968 \| MED12 \| 3.348 \| DISEASES 9439 \| MED23 \| 1.239 \| DISEASES 81857 \| MED25 \| 1.578 \| DISEASES 2315 \| MLANA \| 1.486 \| DISEASES 4311 \| MME \| 1.149 \| DISEASES 4318 \| MMP9 \| 1.036 \| DISEASES 2475 \| MTOR \| 3.262 \| DISEASES 4609 \| MYC \| 2.991 \| DISEASES 150372 \| NFAM1 \| 1.796 \| DISEASES 4926 \| NUMA1 \| 1.152 \| DISEASES 4942 \| OAT \| 1.001 \| DISEASES 29948 \| OSGIN1 \| 1.468 \| DISEASES 23241 \| PACS2 \| 1.78 \| DISEASES 5154 \| PDGFA \| 1.543 \| DISEASES 5155 \| PDGFB \| 2.179 \| DISEASES 5203 \| PFDN4 \| 2.005 \| DISEASES 5208 \| PFKFB2 \| 1.086 \| DISEASES 5228 \| PGF \| 1.263 \| DISEASES 26227 \| PHGDH \| 1.117 \| DISEASES 23533 \| PIK3R5 \| 1.028 \| DISEASES 5328 \| PLAU \| 1.407 \| DISEASES 5329 \| PLAUR \| 1.342 \| DISEASES 5336 \| PLCG2 \| 1.943 \| DISEASES 56342 \| PPAN \| 1.452 \| DISEASES 639 \| PRDM1 \| 1.238 \| DISEASES 5590 \| PRKCZ \| 2.413 \| DISEASES 29968 \| PSAT1 \| 1.307 \| DISEASES 5743 \| PTGS2 \| 1.441 \| DISEASES 5747 \| PTK2 \| 2.56 \| DISEASES 2185 \| PTK2B \| 1.31 \| DISEASES 5788 \| PTPRC \| 3.021 \| DISEASES 90780 \| PYGO2 \| 1.103 \| DISEASES 8480 \| RAE1 \| 1.759 \| DISEASES 2889 \| RAPGEF1 \| 1.051 \| DISEASES 64783 \| RBM15 \| 2.487 \| DISEASES 9939 \| RBM8A \| 1.884 \| DISEASES 3516 \| RBPJ \| 4.687 \| DISEASES 1827 \| RCAN1 \| 1.045 \| DISEASES 5965 \| RECQL \| 1.515 \| DISEASES 5970 \| RELA \| 2.123 \| DISEASES 387 \| RHOA \| 1.973 \| DISEASES 6041 \| RNASEL \| 1.489 \| DISEASES 6093 \| ROCK1 \| 1.102 \| DISEASES 6144 \| RPL21 \| 1.288 \| DISEASES 6195 \| RPS6KA1 \| 3.006 \| DISEASES 6196 \| RPS6KA2 \| 3.345 \| DISEASES 6197 \| RPS6KA3 \| 3.169 \| DISEASES 6295 \| SAG \| 1.28 \| DISEASES 84324 \| SARNP \| 1.362 \| DISEASES 6401 \| SELE \| 2.207 \| DISEASES 26054 \| SENP6 \| 1.281 \| DISEASES 5265 \| SERPINA1 \| 1.009 \| DISEASES 25970 \| SH2B1 \| 1.27 \| DISEASES 6450 \| SH3BGR \| 2.685 \| DISEASES 6451 \| SH3BGRL \| 2.514 \| DISEASES 6614 \| SIGLEC1 \| 1.375 \| DISEASES 4090 \| SMAD5 \| 1.301 \| DISEASES 9126 \| SMC3 \| 1.996 \| DISEASES 26770 \| SNORD79 \| 1.791 \| DISEASES 6693 \| SPN \| 1.117 \| DISEASES 6714 \| SRC \| 3.029 \| DISEASES 6731 \| SRP72 \| 1.047 \| DISEASES 10772 \| SRSF10 \| 1.268 \| DISEASES 6428 \| SRSF3 \| 1.674 \| DISEASES 54879 \| ST7L \| 1.583 \| DISEASES 246329 \| STAC3 \| 1.12 \| DISEASES 10617 \| STAMBP \| 1.324 \| DISEASES 6772 \| STAT1 \| 2.151 \| DISEASES 8801 \| SUCLG2 \| 1.118 \| DISEASES 7341 \| SUMO1 \| 1.959 \| DISEASES 6613 \| SUMO2 \| 3.542 \| DISEASES 6612 \| SUMO3 \| 3.571 \| DISEASES 6839 \| SUV39H1 \| 1.795 \| DISEASES 6850 \| SYK \| 1.307 \| DISEASES 26115 \| TANC2 \| 1.848 \| DISEASES 29110 \| TBK1 \| 1.79 \| DISEASES 7010 \| TEK \| 1.062 \| DISEASES 7058 \| THBS2 \| 1.49 \| DISEASES 7075 \| TIE1 \| 1.677 \| DISEASES 7124 \| TNF \| 2.863 \| DISEASES 8718 \| TNFRSF25 \| 2.029 \| DISEASES 7293 \| TNFRSF4 \| 1.151 \| DISEASES 8771 \| TNFRSF6B \| 1.002 \| DISEASES 27010 \| TPK1 \| 1.43 \| DISEASES 7187 \| TRAF3 \| 1.423 \| DISEASES 10346 \| TRIM22 \| 1.187 \| DISEASES 7874 \| USP7 \| 1.868 \| DISEASES 7407 \| VARS \| 1.108 \| DISEASES 7421 \| VDR \| 1.326 \| DISEASES 7422 \| VEGFA \| 3.9 \| DISEASES 79001 \| VKORC1 \| 1.091 \| DISEASES 51160 \| VPS28 \| 2.202 \| DISEASES 51028 \| VPS36 \| 2.235 \| DISEASES 7453 \| WARS \| 1.787 \| DISEASES 6375 \| XCL1 \| 1.104 \| DISEASES 7520 \| XRCC5 \| 1.613 \| DISEASES 91746 \| YTHDC1 \| 1.818 \| DISEASES
Locus	(Waiting for update.)

Disease ID	108
Disease	kaposi sarcoma
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:29) HP:0012733 \| Macule HP:0200035 \| Skin plaque HP:0012378 \| Fatigue HP:0001824 \| Weight loss HP:0001004 \| Lymphedema HP:0008069 \| Neoplasm of the skin HP:0001034 \| Hyperpigmented spots HP:0005353 \| Susceptibility to herpesvirus HP:0000479 \| Abnormality of the retina HP:0005523 \| Lymphoproliferative disorder HP:0002014 \| Diarrhea HP:0011793 \| Neoplasm by anatomical site HP:0008940 \| Generalized lymphadenopathy HP:0001028 \| Hemangioma HP:0002664 \| Neoplasia HP:0002088 \| Abnormality of lung morphology HP:0002814 \| Abnormality of the lower limb HP:0005293 \| Venous insufficiency HP:0001392 \| Abnormality of the liver HP:0001945 \| Fever HP:0000969 \| Dropsy HP:0000988 \| Skin rash HP:0001298 \| Encephalopathy HP:0002721 \| Immunodeficiency HP:0001034 \| Hypermelanotic macule HP:0200036 \| Skin nodule HP:0011024 \| Abnormality of the gastrointestinal tract HP:0200034 \| Papule HP:0001743 \| Abnormality of the spleen
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:52) HP:0002665 \| Lymphoma \| 7 HP:0002664 \| Neoplasia \| 7 HP:0100242 \| Sarcoma \| 7 HP:0002721 \| Immunodeficiency \| 4 HP:0100726 \| Kaposi's sarcoma \| 4 HP:0012189 \| Hodgkin disease \| 3 HP:0012539 \| Non-Hodgkin lymphoma \| 3 HP:0002840 \| Lymphadenitis \| 2 HP:0200034 \| Papule \| 2 HP:0012578 \| Membranous glomerulonephritis \| 2 HP:0002202 \| Pleural effusion \| 2 HP:0005523 \| Lymphoproliferative disorder \| 2 HP:0002835 \| Aspiration \| 1 HP:0012490 \| Inflammation of fat tissue \| 1 HP:0002583 \| Colitis \| 1 HP:0001369 \| Arthritis \| 1 HP:0002488 \| Acute leukemias \| 1 HP:0100843 \| Glioblastoma \| 1 HP:0012034 \| Liposarcoma \| 1 HP:0001909 \| Leukemia \| 1 HP:0002013 \| Emesis \| 1 HP:0002584 \| Intestinal hemorrhage \| 1 HP:0001271 \| Polyneuropathy \| 1 HP:0003765 \| Psoriasis \| 1 HP:0100742 \| Vascular neoplasm \| 1 HP:0002239 \| Gastrointestinal hemorrhage \| 1 HP:0001541 \| Ascites \| 1 HP:0002242 \| Enteropathy \| 1 HP:0000083 \| Renal insufficiency \| 1 HP:0002860 \| Squamous cell carcinoma \| 1 HP:0000969 \| Dropsy \| 1 HP:0006775 \| Multiple myeloma \| 1 HP:0004315 \| IgG deficiency \| 1 HP:0001251 \| Ataxia \| 1 HP:0002716 \| Lymph node hyperplasia \| 1 HP:0001045 \| Blotchy loss of skin color \| 1 HP:0012191 \| B-cell lymphoma \| 1 HP:0012203 \| Onychomycosis \| 1 HP:0001945 \| Fever \| 1 HP:0100279 \| Ulcerative colitis \| 1 HP:0001370 \| Rheumatoid arthritis \| 1 HP:0009725 \| Bladder neoplasm \| 1 HP:0003473 \| Fatigable weakness \| 1 HP:0003774 \| End-stage renal failure \| 1 HP:0002243 \| Protein-losing enteropathy \| 1 HP:0001047 \| Atopic dermatitis \| 1 HP:0000099 \| Glomerular nephritis \| 1 HP:0003003 \| Colon cancer \| 1 HP:0001004 \| Lymphatic obstruction \| 1 HP:0002955 \| Granulomatosis \| 1 HP:0009733 \| Glioma \| 1 HP:0030731 \| Carcinoma \| 1

Disease ID	108
Disease	kaposi sarcoma
Manually Symptom	UMLS \| Name(Total Manually Symptoms:13) C1619738 \| immune reconstitution inflammatory syndrome C0748159 \| pulmonary involvement C0333243 \| pitting edema C0221383 \| phlegmonous gastritis C0079731 \| b-cell non-hodgkin's lymphoma C0037284 \| skin lesion C0026764 \| multiple myeloma C0021832 \| intestinal parasites C0020758 \| ichthyosis C0020437 \| hypercalcemia C0017575 \| necrotizing gingivitis C0005398 \| extrahepatic cholestasis C0004623 \| bacterial infections
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:12) C0009450 \| infection \| 16 C0019693 \| hiv infection \| 3 C0024299 \| lymphomas \| 2 C0024305 \| non-hodgkin lymphoma \| 2 C1619738 \| immune reconstitution inflammatory syndrome \| 2 C0001175 \| acquired immunodeficiency syndrome \| 2 C0748159 \| pulmonary involvement \| 1 C0037284 \| skin lesions \| 1 C0079731 \| b-cell lymphoma \| 1 C0030805 \| bullous pemphigoid \| 1 C0017531 \| castleman's disease \| 1 C1334815 \| multicentric castleman's disease \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:4)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1800795	15154666	3569	IL6	umls:C0036220	GAD	[In addition to the HHV-8 infection, the interleukin-6 promoter polymorphism G-174C is associated with a risk of development of KS in renal transplant recipients.]	0.130172833	2004	IL6;LOC541472	7	22727026	C	G
rs200895370	24522099	84634	KISS1R	umls:C0036220	BeFree	Two rare heterozygous variants (c.442C>T (p.Arg148Trp) and c.1421G>A (p.Arg474Gln)) in SEMA7A were found in one male nHH patient with a previously identified KISS1R nonsense variant and one male KS patient with a previously identified mutation in KAL1, respectively.	0.000271442	2013	SEMA7A	15	74417900	G	A
rs200895370	24522099	3730	KAL1	umls:C0036220	BeFree	Two rare heterozygous variants (c.442C>T (p.Arg148Trp) and c.1421G>A (p.Arg474Gln)) in SEMA7A were found in one male nHH patient with a previously identified KISS1R nonsense variant and one male KS patient with a previously identified mutation in KAL1, respectively.	0.000271442	2013	SEMA7A	15	74417900	G	A
rs200895370	24522099	8482	SEMA7A	umls:C0036220	BeFree	Two rare heterozygous variants (c.442C>T (p.Arg148Trp) and c.1421G>A (p.Arg474Gln)) in SEMA7A were found in one male nHH patient with a previously identified KISS1R nonsense variant and one male KS patient with a previously identified mutation in KAL1, respectively.	0.000271442	2013	SEMA7A	15	74417900	G	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:6)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0001743	Abnormality of the spleen	MP:0004485	increased response of heart to induced stress	increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding
HP:0001392	Abnormality of the liver	MP:0020010	decreased bone mineral density of femur	reduction in the quatitative measurment value of mineral content of bone in the long bone of the thigh
HP:0008069	Neoplasm of the skin	MP:0011205	excessive folding of visceral yolk sac	the appearance of wrinkles or folds on the surface of the visceral yolk sac
HP:0002814	Abnormality of the lower limb	MP:0004686	decreased length of long bones	reduced end-to-end length of the several elongated bones of the extremities
HP:0005353	Susceptibility to herpesvirus	MP:0020001	decreased response to antigen	decreased or weak immune response after exposure to an antigen
HP:0001824	Weight loss	MP:0005114	premature hair loss	release of fur at an earlier than expected time

Mapped by homologous gene(Total Items:21)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0005293	Venous insufficiency	MP:0020254	decreased collagen level	decreased level of the main structural protein of the various connective tissues in animals
HP:0200034	Papule	MP:0013745	abnormal eyelid margin morphology	any structural anomaly of the confluence of the mucosal surface of the conjunctiva, the edge of the orbicularis, and the cutaneous epithelium
HP:0001945	Fever	MP:0020254	decreased collagen level	decreased level of the main structural protein of the various connective tissues in animals
HP:0001824	Weight loss	MP:0020220	decreased tear production	decreased production of the amount of fluid produced in the eye
HP:0008069	Neoplasm of the skin	MP:0020329	decreased capillary density	reduction in the number of capillaries in a given cross-sectional area of a tissue
HP:0005353	Susceptibility to herpesvirus	MP:0020154	impaired humoral immune response	impaired response of the immune system that mediates secreted antibodies produced in B cells
HP:0001028	Hemangioma	MP:0014171	increased fatty acid oxidation	increased rate or incidence of the process of removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydr
HP:0002664	Neoplasm	MP:0020154	impaired humoral immune response	impaired response of the immune system that mediates secreted antibodies produced in B cells
HP:0000969	Edema	MP:0020154	impaired humoral immune response	impaired response of the immune system that mediates secreted antibodies produced in B cells
HP:0002721	Immunodeficiency	MP:0020316	decreased vascular endothelial cell proliferation	decrease in the expansion rate of any vascular endothelial cell population by cell division
HP:0200036	Skin nodule	MP:0013601	increased testis apoptosis	increase in the number of cells of the male reproductive glands undergoing programmed cell death
HP:0001743	Abnormality of the spleen	MP:0013696	increased granulocyte monocyte progenitor cell number	increase in the number of a hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages; these cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1
HP:0001392	Abnormality of the liver	MP:0020169	increased thyroid gland weight	higher than average weight of the thyroid gland
HP:0001034	Hypermelanotic macule	MP:0020154	impaired humoral immune response	impaired response of the immune system that mediates secreted antibodies produced in B cells
HP:0005523	Lymphoproliferative disorder	MP:0013696	increased granulocyte monocyte progenitor cell number	increase in the number of a hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages; these cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1
HP:0002014	Diarrhea	MP:0020220	decreased tear production	decreased production of the amount of fluid produced in the eye
HP:0002814	Abnormality of the lower limb	MP:0013616	decreased volumetric bone mineral density	reduction in the mineral mass per unit volume of bone, the hard, rigid form of connective tissue constituting most of the skeleton of vertebrates and composed chiefly of calcium salts; this is expressed as the amount of mineral per cubic cm of bone (usual
HP:0001004	Lymphedema	MP:0014171	increased fatty acid oxidation	increased rate or incidence of the process of removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydr
HP:0012378	Fatigue	MP:0013659	abnormal erythroid lineage cell morphology	any structural anomaly of an immature or mature cell in the lineage leading to and including erythrocytes
HP:0001298	Encephalopathy	MP:0020187	altered susceptibility to prion infection	altered likelihood that an organism will develop ill effects from the small proteinaceous infectious particles which are resistant to inactivation by procedures that modify nucleic acids and which contain an abnormal isoform of a cellular protein that is
HP:0000988	Skin rash	MP:0020154	impaired humoral immune response	impaired response of the immune system that mediates secreted antibodies produced in B cells

Disease ID	108
Disease	kaposi sarcoma
Case	(Waiting for update.)